Human Dendritic Cells Diagram. In human beings the hematopoietic stem cells located in the bone marrow have been shown to first differentiate into multi lymphoid progenitors and granulocyte macrophage progenitor cells before giving rise to the human equivalent of macrophage dendritic cell progenitors or common dendritic cell progenitors. Dendritic cells and their immature counterparts langerhans cells lc are highly specialized professional antigen presenting cells apc located in the skin mucosa and lymphoid tissues.
They act as messengers between the innate and the adaptive immune systems. Dendritic cells and their immature counterparts langerhans cells lc are highly specialized professional antigen presenting cells apc located in the skin mucosa and lymphoid tissues. Paul langerhans first described dcs in human skin in 1868 but thought they were cutaneous nerve cells.
Human fetal t cells first appear in the thymus at 10 weeks ega whereas nk cells have been detected in fetal liver at 9 weeks ega.
Dendritic cell logo and icon style illustration in red and white outline. An overview of the function ontogeny and phenotype of each cell type can be found by clicking through to the individual pages listed below. Commensal oral bacteria antigens prime human dendritic cells to induce th1 th2 or treg differentiation. Their phenotypic and functional heterogeneity points to their great plasticity and ability to modulate according to their.