Hemagglutinin Diagram. First the three binding sites at the top of the spike bind to sugars on cellular proteins shown in green at the top left pdb entry 1hge. C diagram of an influenza a or b virus.
However the structural basis of the mechanism underlying fusion inhibition by arbidol has remained obscure thereby hindering its further development as a specific and optimized influenza therapeutic. High cleavability of the hemagglutinin mediating virus entry into the vascular system on one hand and restricted receptor expression and polar budding to prevent spread of infection into tissues surrounding endothelia on. The broad spectrum antiviral drug arbidol shows efficacy against influenza viruses by targeting the hemagglutinin ha fusion machinery.
The broad spectrum antiviral drug arbidol shows efficacy against influenza viruses by targeting the hemagglutinin ha fusion machinery.
C diagram of an influenza a or b virus. The viral structure of measles figure 1. First the three binding sites at the top of the spike bind to sugars on cellular proteins shown in green at the top left pdb entry 1hge. Ha contains a fusion peptide a receptor binding site a metastable structural motif and the transmembrane domain.